If you just want to learn how to do pole, a great way to start is by reading this post.
You can do it, too. Get your body in position, pick your position, learn how to do it, and then come back here.
Just like with just about anything, I recommend that you start slowly—with a bit more practice—then get better at whatever it is you’re trying to improve.
Start here and you’ll build it the hard way. Good luck.
The National Institutes of Health have set aside $700 million dollars to test a drug that blocks the actions of a disease-causing protein made by Alzheimer’s.
The new research will be funded by grants awarded to Alzheimer’s experts with no relation to drug company research funding from the Centers for Disease Control and Prevention.
The money, which will be distributed over the next three years, will come from the National Institutes of Health’s budget, which is the nation’s largest source of public funding to scientists.
Alzheimer’s is a progressive neurological disorder that damages the brain by disrupting its function over time. Some 1,000 people in the United States will die from the disease this year.
The disease is caused by a buildup of defective brain cells called beta amyloid. Beta amyloid is a so-called protein that can’t be broken down by normal processes. That leads to inflammation, eventually killing the beta cells, leaving the brain vulnerable.
The new study’s first author, neurobiologist David K. Hecht, will describe results of the study this week at the American Association for the Advancement of Science’s annual meeting in San Diego, California.
The research will be done with a compound called AZD-001. It is a member of a class of small molecules called cytokines, which are proteins that are released by bacteria to cause damage to their hosts.
The drug targets one of the brain’s key molecules, which is called BACE1. Hecht and colleagues found that a gene that helps produce the protein activates when it’s disrupted and blocks BACE1-producing activity.
“That’s what this is designed to find out,” Hecht said.
It’s not clear whether this would be a good drug to use, according to Daniel Bausch, the executive director of the Alzheimer’s Association, based in Washington, D.C.
“It’s a drug in development that’s going to be tested in
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